There's one song on there that Manson suggested was anything to do with his marriage to Dita Von Teese, and that is WOW, which in itself is deliberately sarcastic anyway.
Besides that, the album has fifteen songs, and yes, whilst some of them observe a more personal, emotion-projected side to Manson's writing, there's tracks like Four Rusted Horses, Arma-Goddamn-Motherfuckin'-Geddon, Blank And White, We're From America or I Have To Look Up Just To See Hell that don't reflect personal issues or relationships whatsoever. Three of them are openly sociological, and the others are more psychological, or just discussing life. Even Pretty As A Swastika, Leave A Scar, Into The Fire and 15 are vocally more salacious or defiant, they're not really about complaints or self-pity. Already there I've talked about nine songs, suggesting that the proportion of the album that genuinely dips into Manson's more emotive writing perspective is vastly outweighed by other themes.
Obviously you or anyone else don't have to actually enjoy the music itself, or even Manson's singing style, but lyrics and supporting aesthetics will define what a song is about, and The High End Of Low gets unfairly overlooked when people consider it to be purely about inter-personal relationships between Manson and one or two other people.
I think in general, the album basically reflects the fact that Manson put himself in a position of confusion with certain aspects of his lifestyle, and so instead of being someone who stands confidently on the fringe of culture sneering at it, he instead found himself feeling lost and unsure of how to stand taller. So you get this mixture of personal themes that seem directed at specific people in some songs, but it's more about Manson's fractured identity and feeling disillusioned with life and the world around him.
It still makes the album sprawl in places, and it has imperfections, but it's definitely not written from the same maudlin perspective that parts of EAT ME, DRINK ME was, and I think that's unfortunately a misinterpretation lots of fans made about it that tarnishes the view people create of it overall.